This study is devoted to investigate the effects of mass eccentricity in seismic responses of base-isolated structures subjected to near field ground motions. Superstructures with 3, 6 and 9 stories and aspect ratios equal to 1, 2 and 3 have been idealized as steel special moment frames resting on a reasonable variety of Triple Concave Friction Pendulum (TCFP) bearings considering different period and damping ratios for the isolators. Three-dimensional linear superstructure mounted on nonlinear isolators are subjected to 3 components of near-field ground motions. Under 25 near-field ground motions, effects of mass eccentricity on the main system parameters are studied. These parameters are selected as the main engineering demands including maximum isolator displacement and base shear as well as peak superstructure acceleration. The results indicate that the mass eccentricities has not a remarkable effect on isolator displacement. In contrary to displacement, torsional effect of mass eccentricity raise the base shear up to 1.75 times in a three-story superstructure. Additionally, mass eccentricity can amplify the roof acceleration of a nine-story model approximately 3 times in comparison with a symmetric superstructure. It is also concluded that eccentricity in the direction of the subjected earthquake has the most impact on base shear while the isolator displacement and roof acceleration has mostly influenced by the eccentricity perpendicular to the earthquake path.